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Synthesis of unsymmetric bile pigments: Mesobilirubin‐VIIIα, 17‐desvinyl‐17‐ethyl‐bilirubin‐VIIIα and 12‐despropionic acid‐12‐ethyl‐mesobilirubin‐XIIIα
Author(s) -
Trull Francesc R.,
Lightner David A.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250435
Subject(s) - chemistry , pigment , bile pigments , ethyl ester , bilirubin , bile acid , organic chemistry , biochemistry , medicine , gastroenterology
The unnatural bile pigments 17‐desvinyl‐17‐ethylbilirubin‐VIIIα, mesobilirubin‐VIIIα and 12‐despropionic acid‐12‐ethyl mesobilirubin‐XIIIα were synthesized via (1) “reverse scrambling” of bilirubin‐XIIIα or mesobilirubin‐IXα with mesobilirubin‐IVα or etiobilirubin‐IV‐γ or (2) following coupling of xanthobilirubic acid methyl ester with ψ‐xanthobilirubic acid methyl ester, or coupling of xanthobilirubic acid methyl ester with kryptopyrromethenone.