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1,3‐Dipolar cycloadditions of mesitonitrile oxide with (9‐fluorenylidene)‐aceto‐ and malono‐nitriles. Synthesis of mono ‐ and bis ‐1,2,4‐oxadiazolylmethane derivatives
Author(s) -
Lianis Pygmalion S.,
Rodios Nestor A.,
Alexandrou Nicholas E.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250410
Subject(s) - chemistry , acetonitriles , oxide , medicinal chemistry , nitrile , aryl , derivative (finance) , organic chemistry , acetonitrile , alkyl , financial economics , economics
Mesitonitrile oxide reacts with C ≡ N bond of (aryl)(9‐fluorenylidene)acetonitriles 1 forming in very good yields the corresponding 1,2,4‐oxadiazoles 2. Analogously also proceeds the reaction of mesitonitrile oxide with 9‐fluorenylidenemalonodinitrile (3) with the formation of bis ‐1,2,4‐oxadiazole derivative 4.