The synthesis of 1,3‐dihydro‐1‐[1‐[(4‐methyl‐4 H ‐6 H ‐pyrrolo[1,2‐ a ][4,1]benzoxazepin‐4‐yl)methyl]‐4‐piperidinyl]‐2 H ‐benzimidazol‐2‐one (1:1) maleate (CGS 9343 B, potent calmodulin inhibitor) | Zendy

Boyer S. | Zendy; Blazier E. | Zendy; Barabi M. | Zendy; Long G. | Zendy; Zaunius G. | Zendy; Wasley J. W. F. | Zendy; Hamdan A. | Zendy

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The synthesis of 1,3‐dihydro‐1‐[1‐[(4‐methyl‐4 H ‐6 H ‐pyrrolo[1,2‐ a ][4,1]benzoxazepin‐4‐yl)methyl]‐4‐piperidinyl]‐2 H ‐benzimidazol‐2‐one (1:1) maleate (CGS 9343 B, potent calmodulin inhibitor)

Author(s) -

Boyer S.,

Blazier E.,

Barabi M.,

Long G.,

Zaunius G.,

Wasley J. W. F.,

Hamdan A.

Publication year - 1988

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570250357

Subject(s) - chemistry , yield (engineering) , ring (chemistry) , tricyclic , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , materials science , metallurgy

A practical synthesis of the title compound 7b is described in seven steps in approximately 10% overall yield. The key step in the synthesis is the formation of the unusual tricyclic ring system 4 via acid catalyzed cyclization.

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