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The synthesis of 1,3‐dihydro‐1‐[1‐[(4‐methyl‐4 H ‐6 H ‐pyrrolo[1,2‐ a ][4,1]benzoxazepin‐4‐yl)methyl]‐4‐piperidinyl]‐2 H ‐benzimidazol‐2‐one (1:1) maleate (CGS 9343 B, potent calmodulin inhibitor)
Author(s) -
Boyer S.,
Blazier E.,
Barabi M.,
Long G.,
Zaunius G.,
Wasley J. W. F.,
Hamdan A.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250357
Subject(s) - chemistry , yield (engineering) , ring (chemistry) , tricyclic , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , materials science , metallurgy
A practical synthesis of the title compound 7b is described in seven steps in approximately 10% overall yield. The key step in the synthesis is the formation of the unusual tricyclic ring system 4 via acid catalyzed cyclization.