Premium
Synthesis of pyrrolo[1,2‐ b ]cinnolines
Author(s) -
Hamer R. Richard L.,
Sekerak Danette,
Effland Richard C.,
Klein Joseph T.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250355
Subject(s) - chemistry , cinnoline , intramolecular force , electrophile , reagent , combinatorial chemistry , carbamic acid , stereochemistry , organic chemistry , catalysis
The synthesis of the pyrrolo[1,2‐ b ]cinnoline analogs 2 and 4–13 is described. The key step of this synthesis involves an intramolecular aromatic halide displacement on [2‐(2‐halobenzoyl)pyrrol‐1‐yl]carbamic acid esters. Several reactions of these cinnoline analogs with electrophilic reagents have been investigated.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom