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Synthesis of pyrrolo[1,2‐ b ]cinnolines
Author(s) -
Hamer R. Richard L.,
Sekerak Danette,
Effland Richard C.,
Klein Joseph T.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250355
Subject(s) - chemistry , cinnoline , intramolecular force , electrophile , reagent , combinatorial chemistry , carbamic acid , stereochemistry , organic chemistry , catalysis
The synthesis of the pyrrolo[1,2‐ b ]cinnoline analogs 2 and 4–13 is described. The key step of this synthesis involves an intramolecular aromatic halide displacement on [2‐(2‐halobenzoyl)pyrrol‐1‐yl]carbamic acid esters. Several reactions of these cinnoline analogs with electrophilic reagents have been investigated.