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Coupling reactions of aryl and heteroaryl halides with a trimethylsilylethynylpyrazine
Author(s) -
Akita Yasuo,
Kanekawa Hideta,
Kawasaki Tatsuya,
Shiratori Ikuko,
Ohta Akihiro
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250352
Subject(s) - chemistry , halide , aryl , acetylene , coupling (piping) , medicinal chemistry , solvent , coupling reaction , computational chemistry , organic chemistry , catalysis , alkyl , mechanical engineering , engineering
By the coupling reactions of trimethylsilylacetylene and 2‐chloro‐3,6‐diisobutylpyrazine, 3,6‐diisobutyl‐2‐trimethylsilylethynylpyrazine or 1,2‐bis(3,6‐diisobutylpyrazin‐2‐yl)acetylene was obtained, depending on the solvent used. The former substance coupled with various aryl and heteroaryl halides to give 1‐aryl‐2‐pyrazin‐ylacetylenes.