Synthesis of 4,12‐dihydro‐4‐oxoquino‐[1,8a,8‐ a,b ]quinoxaline‐5‐carboxylic acid derivatives | Zendy

Chu Daniel T. W. | Zendy; Maleczka Robert E. | Zendy; Nordeen Carl W. | Zendy

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Synthesis of 4,12‐dihydro‐4‐oxoquino‐[1,8a,8‐ a,b ]quinoxaline‐5‐carboxylic acid derivatives

Author(s) -

Chu Daniel T. W.,

Maleczka Robert E.,

Nordeen Carl W.

Publication year - 1988

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570250343

Subject(s) - chemistry , quinoxaline , carboxylic acid , intramolecular force , nucleophile , medicinal chemistry , intramolecular reaction , stereochemistry , organic chemistry , catalysis

The synthesis and antibacterial activity of 1‐substituted amino‐2‐fluoro‐4,12‐dihydro‐4‐oxoquino[1,8a,8‐ a,b ]quinoxaline‐5‐carboxylic acid derivatives are described. The synthetic route includes a carbon homologation and two intramolecular nucleophilic displacement cyclization reactions leading to the novel 4,12‐dihydro‐4‐oxoquino[1,8a,8‐ a,b ]quinoxaline‐5‐carboxylic acid heterocycle.

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