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Synthesis of 4,12‐dihydro‐4‐oxoquino‐[1,8a,8‐ a,b ]quinoxaline‐5‐carboxylic acid derivatives
Author(s) -
Chu Daniel T. W.,
Maleczka Robert E.,
Nordeen Carl W.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250343
Subject(s) - chemistry , quinoxaline , carboxylic acid , intramolecular force , nucleophile , medicinal chemistry , intramolecular reaction , stereochemistry , organic chemistry , catalysis
The synthesis and antibacterial activity of 1‐substituted amino‐2‐fluoro‐4,12‐dihydro‐4‐oxoquino[1,8a,8‐ a,b ]quinoxaline‐5‐carboxylic acid derivatives are described. The synthetic route includes a carbon homologation and two intramolecular nucleophilic displacement cyclization reactions leading to the novel 4,12‐dihydro‐4‐oxoquino[1,8a,8‐ a,b ]quinoxaline‐5‐carboxylic acid heterocycle.