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Pyridazines. XXXVII . Novel triazanaphthalene derivatives via intramolecular cyclization reactions of vic ‐disubstituted pyridazines
Author(s) -
Boamah Philip Yaw,
Haider Norbert,
Heinisch Gottfried,
Moshuber Jöran
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250334
Subject(s) - chemistry , acetamide , ketone , intramolecular force , stereochemistry , medicinal chemistry , organic chemistry
Abstract 8‐Phenylpyrido[3,4‐ d ]pyridazines bearing various amino substituents at C‐5 ( 7a‐d, 8 ) were prepared from ethyl 5‐benzyl‐4‐pyridazinecarboxylate 1 via the fused pyridone 5 . The isomeric 4‐phenylpyrido[2,3‐ d ]pyridazines having the amino functions attached to C‐2 ( 10a‐f ) were obtained by a one‐pot cyclization of the amino ketone 1 with appropriate acetamide acetals. These novel triazanaphthalene derivatives are of interest as analogues of diuretic and antithrombotic agents.