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Acid catalyzed hydrolysis of brotizolam, a thienotriazolodiazepine: Spectroscopic study
Author(s) -
Gallo B.,
Alonso R. M.,
Lete E.,
Badía M. D.,
Patriarche G. J.,
Gelbcke M.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250332
Subject(s) - chemistry , hydrolysis , protonation , catalysis , cleavage (geology) , ring (chemistry) , medicinal chemistry , diazepine , bond cleavage , stereochemistry , organic chemistry , ion , geotechnical engineering , fracture (geology) , engineering
The acid catalyzed hydrolysis of the thienotriazolodiazepine, Brotizolam, 2‐bromo‐4‐(2‐chlorophenyl)‐9‐methyl‐6 H ‐thieno[3,2‐ f ][1,2,4]triazolo[4,3‐ a ][1,4]diazepine ( 1 ), has been studied spectrometrically (ir, pmr, cmr, and ms). The cleavage reaction of the azomethine bond is reversible and the open‐ring compound is in equilibrium with the ring closed compound (protonated form of the parent drug).