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A facile synthesis of [1,2,4]triazino[3,2‐ f ]purines and [1,2,4]triazepino[3,2‐ f ]purines
Author(s) -
Ueda Taisei,
Adachi Tsuneyasu,
Nagai ShinIchi,
Sakakibara Jinsaku,
Murata Mitsuo
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250316
Subject(s) - chemistry , purine metabolism , phenylglyoxal , acetylacetone , glyoxal , acetic acid , medicinal chemistry , aldehyde , purine , organic chemistry , catalysis , biochemistry , amino acid , arginine , enzyme
[1,2,4]Triazino[3,2‐ f ]purines 3a‐e and [1,2,4]triazepino[3,2‐ f ]purine 5 were synthesized by the reaction of 7,8‐diamino‐1,3‐dimethylxanthine 1 with diketones such as glyoxal, diacetyl, dibenzoyl, pyruvic aldehyde dimethyl acetal, phenylglyoxal or acetylacetone in acetic acid in the presence of boric acid or polyphosphoric acid.