Cyclocondensation of 3‐amino‐2‐hydrazino‐4(3 H )‐pyrimidinones with dimethyl acetylenedicarboxylate. Formation of 1‐amino‐2,6‐dihydro‐2,6‐dioxo‐1 H ‐pyrimido[1,2‐ b ][1,2,4]triazine‐3‐acetic acid esters | Zendy

Bitha Panayota | Zendy; Hlavka Joseph J. | Zendy; Lin YangI | Zendy

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Cyclocondensation of 3‐amino‐2‐hydrazino‐4(3 H )‐pyrimidinones with dimethyl acetylenedicarboxylate. Formation of 1‐amino‐2,6‐dihydro‐2,6‐dioxo‐1 H ‐pyrimido[1,2‐ b ][1,2,4]triazine‐3‐acetic acid esters

Author(s) -

Bitha Panayota,

Hlavka Joseph J.,

Lin YangI

Publication year - 1988

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570250308

Subject(s) - chemistry , dimethyl acetylenedicarboxylate , pyrimidinones , acetic acid , hydrazone , amino acid , organic chemistry , medicinal chemistry , cycloaddition , catalysis , biochemistry

[(1‐Amino‐6‐hydroxy‐2(1 H )‐pyrimidinylidene)hydrazone]butanedioic acid dimethyl esters 3 , formed from 3‐amino‐2‐hydrazino‐4(3 H )‐pyrimidinones and dimethyl acetylenedicarboxylate in acetic acid at room temperature, underwent a facile, thermal rearrangement to 1‐amino‐2,6‐dihydro‐2,6‐dioxo‐1 H ‐pyrimido‐[1,2‐ b ]‐[1,2,4]triazine‐3‐acetic acid methyl esters 6 in hot acetic acid.

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