Synthesis of 3‐(2‐Aminoethyl)pyrrole Derivatives

3‐(2‐Di‐ n ‐propylaminoethyl)pyrrole (1a) was prepared in good yield by reduction of pyrrole‐3‐( N,N ‐di‐ n ‐propylglyoxamide) (9) with lithium aluminum hydride. 3‐(2‐Di‐ n ‐propylaminoethyl)‐5‐acetylpyrrole (1b) was prepared by first acetylation of 1‐ p ‐toluenesulfonyl‐3‐(2‐di‐ n ‐propylaminoethyl)pyrrole (6) followed by hydrolysis of the p ‐toluenesulfonyl substituent. The starting material 6 was prepared by homologation of 1‐( p ‐toluenesulfonyl)pyrrole‐3‐carboxaldehyde (3) to the corresponding acetaldehyde followed by reductive amination of the latter.