Synthesis of 1‐Aryl‐1 H ‐pyrazolecarbonitriles and related derivatives | Zendy

Beck James R. | Zendy; Lynch Michael P. | Zendy; Wright Fred L. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of 1‐Aryl‐1 H ‐pyrazolecarbonitriles and related derivatives

Author(s) -

Beck James R.,

Lynch Michael P.,

Wright Fred L.

Publication year - 1988

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570250237

Subject(s) - chemistry , pyrazole , aryl , hydrolysis , regioselectivity , carboxylic acid , organic chemistry , dicarboxylic acid , medicinal chemistry , catalysis , alkyl

The synthesis of 1‐aryl‐5‐cyano‐1 H ‐pyrazole‐4‐carboxylic acid, ethyl esters 1 is described. Subsequent chemistry led to relatively simple and unique pyrazole derivatives. Most important of these are 1‐aryl‐5‐(aminocarbonyl)‐1 H ‐pyrazole‐4‐carboxylic acids 2, which are chemical hybridizing agents in wheat and barley. The regioselective hydrolysis of 1‐(3‐chlorophenyl)‐1 H ‐pyrazole‐4,5‐dicarboxylic acid, dimethyl ester (7b) and subsequent chemistry is also described.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research