Synthesis of 7,8,9,10‐tetrahydropyrido[3′,4′:4,5]pyrrolo[2,3‐ c ]quinolines | Zendy

Schönafinger Karl | Zendy; Yasenchak Christine M. | Zendy; Vollman Anne | Zendy; Ong Helen H. | Zendy

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Synthesis of 7,8,9,10‐tetrahydropyrido[3′,4′:4,5]pyrrolo[2,3‐ c ]quinolines

Author(s) -

Schönafinger Karl,

Yasenchak Christine M.,

Vollman Anne,

Ong Helen H.

Publication year - 1988

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570250233

Subject(s) - chemistry , indole test , hydrolysis , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry

A series of structurally novel 7,8,9,10‐tetrahydropyrido[3′,4′:4,5]pyrrolo[2,3‐ c ,]quinolines, 4a‐c , were synthesized via a facile Fischer indole cyclization from the appropriately substituted hydrazinoquinolines 2a‐c . Acetamides 4a,c were hydrolyzed to 5a,b and further converted to tertiary amines 6a‐c . Potent antihypertensive activity has been observed with a number of the title compounds as well as the intermediate 3a .

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