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Synthesis of 7,8,9,10‐tetrahydropyrido[3′,4′:4,5]pyrrolo[2,3‐ c ]quinolines
Author(s) -
Schönafinger Karl,
Yasenchak Christine M.,
Vollman Anne,
Ong Helen H.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250233
Subject(s) - chemistry , indole test , hydrolysis , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry
Abstract A series of structurally novel 7,8,9,10‐tetrahydropyrido[3′,4′:4,5]pyrrolo[2,3‐ c ,]quinolines, 4a‐c , were synthesized via a facile Fischer indole cyclization from the appropriately substituted hydrazinoquinolines 2a‐c . Acetamides 4a,c were hydrolyzed to 5a,b and further converted to tertiary amines 6a‐c . Potent antihypertensive activity has been observed with a number of the title compounds as well as the intermediate 3a .