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Synthesis of some methylfurochromones as potential photochemotherapeutic agents
Author(s) -
Rodighiero P.,
Pastorini G.,
Chilin A.,
Manzini P.,
Guiotto A.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250232
Subject(s) - chemistry , psoralen , furan , ring (chemistry) , combinatorial chemistry , stereochemistry , dna , organic chemistry , biochemistry
A number of new methylfurochromones with a linear psoralen like structure or an angular angelicin like structure were synthetized. The synthesis were performed starting from 7‐hydroxychromones variously methylated on which the furan ring was built. Methyl groups have been introduced into positions which look most promising for enhancement of the photoreactivity of the compound towards DNA.