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Synthesis of 5‐phenylpyrrolo[1,2‐ b ][1,2,5]‐triazepin‐2(3 H )‐ones
Author(s) -
Hamer R. Richard L.,
Effland Richard C.,
Klein Joseph T.,
Huger Francis P.,
Wilker Jeffrey C.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250230
Subject(s) - chemistry , hydrolysis , stereochemistry , organic chemistry
The synthesis of a series of 5‐phenylpyrrolo[1,2‐ b ][1,2,5]triazepin‐2(3 H )‐ones 1 as potential anxiolytic agents is described. Benzoylation of 1‐phthalimidopyrrole, followed by hydrolysis, gave the 1‐amino‐2‐benzoylpyrroles 3 . These were further functionalized to give the penultimate 1‐aminoacetamido‐2‐benzoylpyrroles 8 and 9 , which were cyclized to the target pyrrolotriazepines 1.