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An intramolecular cyclization of 7‐substituted 6‐fluoro‐ 1,8‐naphthyridine and ‐quinoline derivatives
Author(s) -
Nishimura Yoshiro,
Minamida Akira,
Matsumoto JunIchi
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250224
Subject(s) - chemistry , quinoline , intramolecular force , pyrazine , ring (chemistry) , nucleophile , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , catalysis
Abstract A synthesis of 1,4‐oxazine and pyrazine ring systems by an intramolecular cyclization of 7‐substituted 1‐ethyl‐6‐fluoro‐1,4‐dihydro‐4‐oxo‐1,8‐naphthyridine and ‐quinoline derivatives having a nitrogen or oxygen nucleophilic site in the C‐7 appendage was studied. The in vitro antibacterial activities of compounds prepared by this method were tested.