Premium
New synthesis of pyrido[2,3‐ d ]pyrimidines. III . Nucleophilic substitution on 4‐amino‐2‐halo and 2‐amino‐4‐halo‐5,6‐dihydropyrido[2,3‐ d ]pyrimidin‐7(8 H )‐ones
Author(s) -
Victory Pedro,
Crespo Ana,
Garriga Miquel,
Nomen Rosa
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250139
Subject(s) - chemistry , nucleophilic substitution , halo , halogen , substitution (logic) , nucleophile , stereochemistry , group (periodic table) , medicinal chemistry , organic chemistry , catalysis , physics , alkyl , quantum mechanics , galaxy , computer science , programming language
As the third step of a new general synthesis of pyrido[2,3‐ d ]pyrimidines, the substitution of the halogens by several nucleophiles has been carried out. Yields are between good and high in every case, even when 4‐halogenated compounds have a neighbouring methyl group in C5.