New synthesis of pyrido[2,3‐ d ]pyrimidines.  III . Nucleophilic substitution on 4‐amino‐2‐halo and 2‐amino‐4‐halo‐5,6‐dihydropyrido[2,3‐ d ]pyrimidin‐7(8 H )‐ones | Zendy

Victory Pedro | Zendy; Crespo Ana | Zendy; Garriga Miquel | Zendy; Nomen Rosa | Zendy

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New synthesis of pyrido[2,3‐ d ]pyrimidines. III . Nucleophilic substitution on 4‐amino‐2‐halo and 2‐amino‐4‐halo‐5,6‐dihydropyrido[2,3‐ d ]pyrimidin‐7(8 H )‐ones

Author(s) -

Victory Pedro,

Crespo Ana,

Garriga Miquel,

Nomen Rosa

Publication year - 1988

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570250139

Subject(s) - chemistry , nucleophilic substitution , halo , halogen , substitution (logic) , nucleophile , stereochemistry , group (periodic table) , medicinal chemistry , organic chemistry , catalysis , physics , alkyl , quantum mechanics , galaxy , computer science , programming language

As the third step of a new general synthesis of pyrido[2,3‐ d ]pyrimidines, the substitution of the halogens by several nucleophiles has been carried out. Yields are between good and high in every case, even when 4‐halogenated compounds have a neighbouring methyl group in C5.

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