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Synthesis of 2‐nitro‐L‐tryptophan
Author(s) -
Phillips Robert S.,
Cohen Louis A.
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250128
Subject(s) - chemistry , nitration , nitro , tryptophan , derivative (finance) , nitro compound , organic chemistry , combinatorial chemistry , biochemistry , amino acid , alkyl , financial economics , economics
Nitration of N ‐(trifluoroacetyl)‐L‐tryptophan methyl ester provides 40% of the anticipated 6‐nitro product and 6–7% of the novel 2‐nitro derivative. The latter compound is deprotected with aqueous acid to form 2‐nitro‐L‐tryptophan. Analogous nitration of L‐tryptophan gives only the 6‐nitro product.