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On Triazoles. XIII . The reaction of 5‐benzalimino‐1,2,4‐triazoles with substituted acetyl chlorides
Author(s) -
Reiter József,
Pongó László,
Sohár Pál,
Dvortsák Péter
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250125
Subject(s) - chemistry , triethylamine , yield (engineering) , pyrimidine , dimethylformamide , medicinal chemistry , phosphorus , organic chemistry , stereochemistry , materials science , solvent , metallurgy
The reaction of Schiff bases prepared from 1‐ and 2‐substituted‐5‐amino‐1,2,4‐triazoles with phenoxyacetyl chlorides in the presence of triethylamine and a mixture of phosphorus oxychloride and dichloroacetic acid in dimethylformamide to yield β‐lactam 4 , a dihydro‐1,2,4‐triazolo[4,3‐a]pyrimidine‐5(1 H )‐one 5, a 1,2,4‐triazolo[1,5‐ a ]pyrimidin‐5(3 H )‐one 9 and the corresponding 1,2,4‐triazolo[4,3‐ a ]pyrimidine‐5(1 H )‐one 10 derivatives was studied.