Premium
Bioactive heterocyclic analogs of the antitumor drug, podophyllotoxin
Author(s) -
Jurd Leonard
Publication year - 1988
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570250113
Subject(s) - chemistry , podophyllotoxin , sesamol , pyrrolidine , reagent , mannich base , yield (engineering) , organic chemistry , combinatorial chemistry , drug , alkaloid , pharmacology , antioxidant , medicine , materials science , metallurgy
3,4‐Methylenedioxyphenol (sesamol) condenses with pyrrolidine and aromatic aldehydes to yield Mannich bases of type 4 . The Mannich bases react readily with ketonic reagents to form pyrrolidinylbenzopyran derivatives which provide a simple route to antimitotic and bioactive heterocyclic analogs of the anti‐cancer drug, podophyllotoxin.