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A new method for the synthesis of novel 3‐substituted 4‐amino‐8‐ethoxycarbonylpyrazolo[5,1‐ c ][1,2,4]triazines and pyrazolo[1′,5′:3,4][1,2,4]triazino[5,6‐ b ][1,5]benzodiazepines
Author(s) -
Kurasawa Yoshihisa,
Okamoto Yoshihisa,
Takada Atsushi
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240656
Subject(s) - malononitrile , chemistry , ethyl cyanoacetate , salt (chemistry) , pyrazole , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis
Novel 3‐substituted 4‐amino‐8‐ethoxycarbonylpyrazolo[5,1‐ c ][1,2,4]triazines 7,8 were synthesized by the reactions of malononitrile and ethyl cyanoacetate with the pyrazole‐5‐diazonium salt 3 . Moreover, compounds 7,8 were converted into the pyrazolo[1′,5′:3,4][1,2,4]triazino[5,6‐ b ][1,5]benzodiazepines 9, 10 .