Synthesis of hydrazones derived from 2‐substituted‐10‐carboxyphenothiazine hydrazides | Zendy

Tsitsa P. | Zendy; PsarreaSandris A. | Zendy; Sandris C. | Zendy

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Synthesis of hydrazones derived from 2‐substituted‐10‐carboxyphenothiazine hydrazides

Author(s) -

Tsitsa P.,

PsarreaSandris A.,

Sandris C.

Publication year - 1987

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570240632

Subject(s) - chemistry , yield (engineering) , nitrogen atom , ring (chemistry) , amide , hydrazone , ethanol , medicinal chemistry , organic chemistry , nitrogen , reaction conditions , catalysis , materials science , metallurgy

2‐Substituted‐10‐carboxyphenothiazine hydrazides 3 were found to yield hydrazones 5 on reaction with aromatic aldehydes. However, a similar reaction of hydrazides 3 with aliphatic ketones in refluxing ethanol failed to give the expected hydrazones 6 . The corresponding phenothiazines 1 were isolated in this reaction, apparently through alcoholysis of the amide bond to the ring nitrogen atom in 3 .

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