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An improved synthesis of 3‐(1‐imidazolyl)‐2‐alkenoic acid derivatives and related compounds
Author(s) -
Kashima Choji,
Yoshiwara Nobutoshi,
Tajima Tadakuni,
Omote Yoshimori
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240618
Subject(s) - chemistry , sodium hydride , organic chemistry , hydride , combinatorial chemistry , metal
The preparative method of 3‐(1‐imidazolyl)‐2‐alkenoic acid derivatives and the related compounds was improved by the use of strong bases such as sodium hydride in DMF. By this improved method, the preparation of 2‐substituted 3‐(1‐imidazolyl)‐2‐alkenoic acid derivatives was accomplished in good yields.