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New 7‐substituted quinolone antibacterial agents. The synthesis of 1‐ethyl‐1,4‐dihydro‐4‐oxo‐7‐(2‐thiazolyl and 4‐thiazolyl)‐3‐quinolinecarboxylic acids
Author(s) -
Culbertson Townley P.,
Domagala John M.,
Peterson Phred,
Bongers Shan,
Nichols Jeffrey B.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240604
Subject(s) - chemistry , moiety , thiazole , amine gas treating , quinolone , stereochemistry , antibacterial activity , medicinal chemistry , ethyl ester , organic chemistry , antibiotics , bacteria , biochemistry , biology , genetics
A series of 1‐ethyl‐1,4‐dihydro‐4‐oxo‐7‐(4‐thiazolyl)‐3‐quinolinecarboxylic acids and 1‐ethyl‐1,4‐dihydro‐4‐oxo‐7‐(2‐thiazolyl)‐3‐quinolinecarboxylic acids were prepared. Also prepared was 10‐[2‐(aminomethyl)‐4‐thiazolyl]‐9‐fluoro‐2,3‐dihydro‐3‐methyl‐7‐oxo‐7 H ‐pyrido[1,2,3‐ de ][1,4]benzoxazine‐6‐carboxylic acid. Analogs with basic amine substituents on the thiazole moiety were found to have antibacterial activity.