New 7‐substituted quinolone antibacterial agents. The synthesis of 1‐ethyl‐1,4‐dihydro‐4‐oxo‐7‐(2‐thiazolyl and 4‐thiazolyl)‐3‐quinolinecarboxylic acids | Zendy

Culbertson Townley P. | Zendy; Domagala John M. | Zendy; Peterson Phred | Zendy; Bongers Shan | Zendy; Nichols Jeffrey B. | Zendy

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New 7‐substituted quinolone antibacterial agents. The synthesis of 1‐ethyl‐1,4‐dihydro‐4‐oxo‐7‐(2‐thiazolyl and 4‐thiazolyl)‐3‐quinolinecarboxylic acids

Author(s) -

Culbertson Townley P.,

Domagala John M.,

Peterson Phred,

Bongers Shan,

Nichols Jeffrey B.

Publication year - 1987

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570240604

Subject(s) - chemistry , moiety , thiazole , amine gas treating , quinolone , stereochemistry , antibacterial activity , medicinal chemistry , ethyl ester , organic chemistry , antibiotics , bacteria , biochemistry , biology , genetics

A series of 1‐ethyl‐1,4‐dihydro‐4‐oxo‐7‐(4‐thiazolyl)‐3‐quinolinecarboxylic acids and 1‐ethyl‐1,4‐dihydro‐4‐oxo‐7‐(2‐thiazolyl)‐3‐quinolinecarboxylic acids were prepared. Also prepared was 10‐[2‐(aminomethyl)‐4‐thiazolyl]‐9‐fluoro‐2,3‐dihydro‐3‐methyl‐7‐oxo‐7 H ‐pyrido[1,2,3‐ de ][1,4]benzoxazine‐6‐carboxylic acid. Analogs with basic amine substituents on the thiazole moiety were found to have antibacterial activity.

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