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The effect of the steric requirements of trialkylsilyl ethers on ring closure of 1‐(benzylamino)‐3‐chloro‐2‐(trialkylsiloxy)propanesd
Author(s) -
Higgins Robert H.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240554
Subject(s) - chemistry , steric effects , closure (psychology) , ring (chemistry) , trimethylsilyl , medicinal chemistry , stereochemistry , organic chemistry , law , political science
The ring closure of 1‐(benzylamino)‐3‐chloro‐2‐(trialkylsiloxy)propanes to 1‐benzyl‐3‐(trialkylsiloxy)azetidines was investigated. There appears to be little or no advantage in the use of trialkylsilyl substituents larger than trimethylsilyl.