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Studies on decarboxylation reactions. Part 6 . Kinetic study of decarboxylation of 5‐amino‐1,3,4‐oxadiazole‐2‐carboxylic acid and its N ‐phenyl derivatives at high hydrochloric acid concentrations
Author(s) -
Noto Renato,
Werber Giuseppe,
Buccheri Francesco,
Ar Caterina
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240547
Subject(s) - decarboxylation , chemistry , zwitterion , hydrochloric acid , medicinal chemistry , reaction rate constant , kinetic energy , dissociation (chemistry) , dissociation constant , organic chemistry , kinetics , catalysis , molecule , biochemistry , physics , receptor , quantum mechanics
The dissociation constants (K 1 ) of both acids 4a‐c and esters 5a‐c and the rate constants of the decarboxylation reaction of acids 4a‐c have been measured at various high concentrations of hydrochloric acid (0.5‐8.0 M range). The results obtained have enabled us to suggest the probable structure of the zwitterion which undergoes decarboxylation.