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Heterocyclic systems. VIII. synthesis of 1 H ,4 H ‐pyrazolo[4,3‐ f ]pyrrolo[1,2‐ a ]azepine derivatives
Author(s) -
Corelli Federico,
Massa Silvio,
Stefancich Giorgio,
Silvestri Romano
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240544
Subject(s) - azepine , chemistry , propanoic acid , acylation , tricyclic , intramolecular force , derivative (finance) , stereochemistry , ketone , medicinal chemistry , organic chemistry , catalysis , financial economics , economics
The synthesis of the unknown title Compounds is described. The preparation involves intramolecular acylation of 3‐[1‐phenyl‐5‐(1‐pyrryl)pyrazol‐4‐yl]propanoic acid 9 to the tricyclic ketone 10 , which was then transformed into 1 H ,4 H ‐pyrazolo[4,3‐ f ]pyrrolo[1,2‐ a ]azepine 12 and its dihydro derivative 13 by reductive procedures.