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The mass spectral fragmentation of isoxazolyldihydropyridines
Author(s) -
Knerr Gary,
Mckenna John I.,
Quincy David A.,
Natale N. R.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240541
Subject(s) - chemistry , fragmentation (computing) , substituent , isoxazole , cleavage (geology) , metastability , mass spectrum , stereochemistry , bond cleavage , mass spectrometry , organic chemistry , chromatography , geotechnical engineering , computer science , engineering , catalysis , operating system , fracture (geology)
The mass spectral fragmentation of 4‐isoxazolyl‐1,4‐dihydropyridines has been examined with the aid of linked metastable scanning. Three prominent pathways involve (i) O‐N bond cleavage of the isoxazole followed by the loss of R 2 CN, (ii) loss of carboalkoxy from the 3‐ and/or 5‐ position of the dihydropyridine and, (iii) loss of the 4‐isoxazolyl‐substituent.