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Part 4 . Fused pyrimidines. Annelation using formamide to synthesize 2,4‐disubstituted‐pyrimido[4,5‐d]pyrimidines
Author(s) -
Delia Thomas J.,
Niedzinski Jill
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240539
Subject(s) - chemistry , formamide , annulation , reagent , yield (engineering) , solvent , combinatorial chemistry , pyrimidine , stereochemistry , organic chemistry , catalysis , materials science , metallurgy
A one‐step synthesis of 2,4‐disubstituted‐pyrimido[4,5‐ d ]pyrimidines has been investigated. Cyclization of 6‐amino‐2,4‐disubstituted‐pyrimidines with formamide as solvent and reagent affords the title compounds in 50‐70% yield. Strongly electron‐donating groups are required. Based on model compounds, a pathway for the cyclization is suggested. The method is an improvement on previous methods of synthesis, albeit a limited one.