Part  4 . Fused pyrimidines. Annelation using formamide to synthesize 2,4‐disubstituted‐pyrimido[4,5‐d]pyrimidines | Zendy

Delia Thomas J. | Zendy; Niedzinski Jill | Zendy

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Part 4 . Fused pyrimidines. Annelation using formamide to synthesize 2,4‐disubstituted‐pyrimido[4,5‐d]pyrimidines

Author(s) -

Delia Thomas J.,

Niedzinski Jill

Publication year - 1987

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570240539

Subject(s) - chemistry , formamide , annulation , reagent , yield (engineering) , solvent , combinatorial chemistry , pyrimidine , stereochemistry , organic chemistry , catalysis , materials science , metallurgy

A one‐step synthesis of 2,4‐disubstituted‐pyrimido[4,5‐ d ]pyrimidines has been investigated. Cyclization of 6‐amino‐2,4‐disubstituted‐pyrimidines with formamide as solvent and reagent affords the title compounds in 50‐70% yield. Strongly electron‐donating groups are required. Based on model compounds, a pathway for the cyclization is suggested. The method is an improvement on previous methods of synthesis, albeit a limited one.

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