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An improved, large‐scale synthesis of xanthothricin and reumycin
Author(s) -
Black T. Howard
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240529
Subject(s) - chemistry , yield (engineering) , scale (ratio) , combinatorial chemistry , scale up , organic chemistry , physics , materials science , quantum mechanics , metallurgy , classical mechanics
Xanthothricin (toxoflavin) has been synthesized in high yield and on a large (over 100 g) scale; this was selectively demethylated at N‐1 to produce reumycin (1‐demethyltoxoflavin) employing an optimized purification protocol also amenable to large‐scale production.