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Polycondensed nitrogen heterocycles. Part 17 . Isoxazolo[4,3‐ d ]pyrazolo[3,4‐ f ][1,2,3]triazepine. A new ring system
Author(s) -
Almerico Anna Maria,
Dattolo Gaetano,
Cirrincione Girolamo,
Presti Giuseppe,
Aiello Enrico
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240515
Subject(s) - chemistry , nitration , ring (chemistry) , intramolecular force , medicinal chemistry , nitrogen , clostridium perfringens , stereochemistry , organic chemistry , bacteria , biology , genetics
The title compounds were prepared by nitration of compounds 2 , reduction of the dinitro derivatives 4 and diazotization of the diamino derivatives 6 followed by an intramolecular coupling reaction. Compound 4a showed good activity against Salmonella cholerasuis and Clostridium perfringens bacteria.