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Oxamic acid derivaties in heterocyclic synthesis: Preparation of 1,2,4‐triazolo[1,5‐ a ]pyrazine derivatives
Author(s) -
Molina P.,
Vilaplana Ma. J.,
Andreu P. L.,
Møller J.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240509
Subject(s) - chemistry , thionyl chloride , pyrazine , ring (chemistry) , chloride , closure (psychology) , aryl , medicinal chemistry , organic chemistry , combinatorial chemistry , alkyl , economics , market economy
N ‐Aryl‐ N ‐(α‐phenylphenacyl)oxamoyl chlorides react with N 3 ‐arylsubstituted amidrazones to give functionalized 1,2,4‐triazoles which undergo ring‐closure by the action of thionyl chloride to give 1,2,4‐triazolo[1,5‐ a ]‐pyrazinium chlorides in excellent yields.