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N ‐Arylation of isatins. A direct route to N ‐arylisatoic anhydrides
Author(s) -
Coppola Gary M.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240503
Subject(s) - chemistry , isatin , aryl , bromide , sequence (biology) , oxide , combinatorial chemistry , organic chemistry , alkyl , biochemistry
The synthesis of N ‐arylisatoic anhydrides 3 has been accomplished by using a two‐step process. The key reaction in the sequence is the direct N ‐arylation of isatin with an aryl bromide in the presence of cupric oxide. Subsequent oxidation of the resulting N ‐aryl isatin 2 with m ‐chloroperoxybenzoic acid furnishes the desired products.