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Reaction of 5‐(substituted‐amino)oxazoles with N ‐phenylmaleimide
Author(s) -
Shimada Sadakatsu
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240501
Subject(s) - chemistry , pyridine , adduct , tricyclic , medicinal chemistry , stereochemistry , organic chemistry
Reaction of 5‐aminooxazoles with N ‐phenylmaleimide gave 7‐hydroxy‐2‐phenylpyrrolo[3,4‐ c ]pyridine‐1,3‐diones and 7‐amino‐2‐phenylpyrrolo[3,4‐ c ]pyridine‐1,3‐diones via tricyclic adducts. The ratio of the 7‐hydroxy compound and 7‐amino compound depended on the basicity of the leaving group of the adducts. The reaction of 5‐acetaminooxazole with dienophiles is described.