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A new synthesis of aryl hetaryl ketones via S RN 1 reactions of halogenated heterocycles with potassiophenylacetonitrile followed by phase‐transfer catalyzed decyanation
Author(s) -
Hermann Christine K. F.,
Sachdeva Yesh P.,
Wolfe James F.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240429
Subject(s) - chemistry , catalysis , aryl , phase (matter) , ammonia , organic chemistry , phase transfer catalyst , medicinal chemistry , combinatorial chemistry , alkyl
Reaction of halogenated pyridines, quinolines, pyrimidines, and pyrazines with potassiophenylacetonitrile ( 5 ) in liquid ammonia under near‐uv irradiation affords secondary nitriles, which then undergo oxidative decyanation under phase‐transfer catalytic conditions to afford aryl hetaryl ketones in excellent yields.