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Synthesis of 1‐aryl‐5‐(trifluoromethyl)‐1H‐pyrazole‐4‐carboxylic acids and esters
Author(s) -
Beck James R.,
Wright Fred L.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240338
Subject(s) - chemistry , trifluoromethyl , pyrazole , aryl , alkoxy group , ring (chemistry) , amide , condensation , medicinal chemistry , derivative (finance) , organic chemistry , alkyl , physics , thermodynamics , financial economics , economics
Ethyl 1‐aryl‐5‐(trifluoromethyl)‐1 H ‐pyrazole‐4‐carboxylates 2 were prepared by the condensation of arylhydrazines with ethyl 3‐ethoxy‐2‐(trifluoroacetyl)‐2‐propenoate (1a) at low temperature. The corresponding acids were also synthesized. X‐ray diffraction analysis of an amide derivative 4 verified the position of the trifluoromethyl group on the pyrazole ring.