Synthesis of 1‐aryl‐5‐(trifluoromethyl)‐1H‐pyrazole‐4‐carboxylic acids and esters | Zendy

Beck James R. | Zendy; Wright Fred L. | Zendy

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Synthesis of 1‐aryl‐5‐(trifluoromethyl)‐1H‐pyrazole‐4‐carboxylic acids and esters

Author(s) -

Beck James R.,

Wright Fred L.

Publication year - 1987

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570240338

Subject(s) - chemistry , trifluoromethyl , pyrazole , aryl , alkoxy group , ring (chemistry) , amide , condensation , medicinal chemistry , derivative (finance) , organic chemistry , alkyl , physics , thermodynamics , financial economics , economics

Ethyl 1‐aryl‐5‐(trifluoromethyl)‐1 H ‐pyrazole‐4‐carboxylates 2 were prepared by the condensation of arylhydrazines with ethyl 3‐ethoxy‐2‐(trifluoroacetyl)‐2‐propenoate (1a) at low temperature. The corresponding acids were also synthesized. X‐ray diffraction analysis of an amide derivative 4 verified the position of the trifluoromethyl group on the pyrazole ring.

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