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Synthesis of 2′,3′‐dihydrospiro[benzofuran‐2(3H),4′(1′‐H)isoquinoline]s. A novel heterocyclic ring system
Author(s) -
Klein Joseph T.,
Davis Larry,
Effland Richard C.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240336
Subject(s) - isoquinoline , chemistry , benzofuran , ring (chemistry) , nucleophile , medicinal chemistry , stereochemistry , organic chemistry , catalysis
The synthesis of a novel 2′,3′‐dihydrospiro(benzofuran‐2(3 H ),4′(1′ H )isoquinoline] ring system ( IV ) by a nucleophilic aromatic fluoride displacement‐cyclization is described. Preparation of various derivatives of IV as well as the precursor 4‐(2‐fluorobenzyl)‐1,2,3,4‐tetrahydro‐4‐isoquinolinols is also described.
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