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Quinazolines and 1,4‐benzodiazepines. XCVI . Compounds derived from benzodiazepine‐2‐acetic acid
Author(s) -
Walser A.,
Flynn T.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240327
Subject(s) - chemistry , benzodiazepine , acetic acid , ring (chemistry) , pharmacology , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , receptor , medicine
1,4‐Benzodiazepine‐2‐acetic acid derivatives were prepared and converted to compounds with a heterocyclic ring fused to the a ‐face of the benzodiazepine system. Representatives of pyrido[1,2‐ a ][1,4]benzodiaze‐pines, pyrimido[1,6‐ a ][1,4]benzodiazepines and [1,3]oxazino[3,4‐ a ][1,4]benzodiazepines are described. Some of the compounds showed marked CNS‐activity as measured by the antimetrazole test which is a well established primary screening method for assessment of benzodiazepine type activity.