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Synthesis and spectra of some triazolo and triazinophthalazines of possible hypotensive activity
Author(s) -
Allah Hassan M. Faid,
Soliman Raafat
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240324
Subject(s) - chemistry , hydralazine , ethyl cyanoacetate , medicinal chemistry , organic chemistry , catalysis , medicine , malononitrile , blood pressure
Abstract Cyclization of hydralazine 1 with acid chlorides or ethyl cyanoacetate gave the appropriate s ‐triazolo derivatives, while with ketoesters or 1,2‐dicyclohexanedione it afforded the as ‐triazino derivatives. Reaction of 1 with ketosteroids yielded hydrazones. Preliminary cardiovascular testing revealed possible hypotensive activity of some of these derivatives.