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Regioselective syntheses of 2‐amino‐4,5‐dialkylthiophene‐3‐carboxylates and their conversion to 3,4‐dihydro‐4‐oxothieno[2,3‐ d ]pyrimidine‐2‐carboxylates
Author(s) -
Madding Gary D.,
Thompson Michael D.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240309
Subject(s) - chemistry , regioselectivity , pyrimidine , catalysis , organic chemistry , combinatorial chemistry , stereochemistry
The synthesis of 3,4‐dihydro‐4‐oxothieno[2,3‐ d ]pyrimidine‐2‐carboxylates via acid catalyzed reactions of various 2‐aminothiophene‐3‐carboxylates with activated nitriles is presented. The requisite thiophenes were prepared regioselectively by methods which represent improvements over previously published procedures.