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Synthesis of 3‐amino‐5 H ‐pyrimido[5,4‐ b ]indol‐4‐one derivatives
Author(s) -
Monge A.,
Palop J. A.,
Parrado P.,
PerezIlzarbe C.,
FernándezAlvarez E.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240226
Subject(s) - chemistry , indole test , stereochemistry , carboxylate , platelet aggregation , amino acid , platelet , biochemistry , immunology , biology
Starting with ethyl 3‐aminoindole‐2‐carboxylate, the synthesis of 3‐amino‐5 H ‐pyrimido[5,4‐ b ]indole‐2,4‐dione 5 , 3‐amino‐5 H ‐pyrimido[5,4‐ b ]indol‐4‐one 10 and some related compounds is described. Preliminary results about the inhibition of platelet aggregation by these compounds is reported.