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On the mechanism of hydrolysis of the triazolobenzodiazepine, triazolam. Spectroscopic study
Author(s) -
Jiménez R. M.,
Domínguez E.,
Badía D.,
Alonso R. M.,
Vicente F.,
Hernández L.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240223
Subject(s) - chemistry , triazolam , benzophenone , hydrolysis , derivative (finance) , imine , bond cleavage , medicinal chemistry , protonation , ring (chemistry) , stereochemistry , photochemistry , computational chemistry , benzodiazepine , organic chemistry , ion , biochemistry , receptor , financial economics , economics , catalysis
The hydrolysis of 8‐chloro‐6‐(2′‐chlorophenyl)‐1‐methyl‐4 H [1,2,4]triazolo[4,3‐ a ][1,4]benzodiazepine (Triazolam) at room temperature, involves a reversible mechanism. The intermediate is a protonated species and the final product is the ring‐opened compound resulting from the reversible scission of the imine bond. The two compounds were determined simultaneously as a function of p H with pmr and cmr spectrometry. Spectral data of the benzophenone derivative II (ir, cmr, pmr) are reported.