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Synthesis of 1,2‐di‐(4‐pyridyl)ethylenediamine and related compounds
Author(s) -
Braña Miguel F.,
Castellano José M.,
Rodriguez Maria L. López,
Gálvez Magdalena,
Amil Manuel R.,
Rubio Enrique
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240215
Subject(s) - ethylenediamine , chemistry , yield (engineering) , hydrolysis , aqueous solution , trifluoroacetic acid , sulfuric acid , medicinal chemistry , organic chemistry , metallurgy , materials science
Hydrolysis of N,N' ‐diacyl‐1,2‐di(4‐pyridyl)ethylenediamines 1 in aqueous sulfuric acid gave the corresponding imidazolines 3. 1,2‐Di‐(4‐pyridyl)ethylenediamine 2 was prepared in 61 % yield by treating N,N'‐di‐t‐ butyl‐oxycarbonyl‐1,2‐di(4‐pyridyl)ethylenediamine 4 with trifluoroacetic acid or in 94% yield by the hydrolysis under basic conditions of N,N' ‐diphthaloylglycyl‐1,2‐di(4‐pyridy)ethylenediamine 13.