Synthesis of 1,2‐di‐(4‐pyridyl)ethylenediamine and related compounds | Zendy

Braña Miguel F. | Zendy; Castellano José M. | Zendy; Rodriguez Maria L. López | Zendy; Gálvez Magdalena | Zendy; Amil Manuel R. | Zendy; Rubio Enrique | Zendy

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Synthesis of 1,2‐di‐(4‐pyridyl)ethylenediamine and related compounds

Author(s) -

Braña Miguel F.,

Castellano José M.,

Rodriguez Maria L. López,

Gálvez Magdalena,

Amil Manuel R.,

Rubio Enrique

Publication year - 1987

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570240215

Subject(s) - ethylenediamine , chemistry , yield (engineering) , hydrolysis , aqueous solution , trifluoroacetic acid , sulfuric acid , medicinal chemistry , organic chemistry , metallurgy , materials science

Hydrolysis of N,N' ‐diacyl‐1,2‐di(4‐pyridyl)ethylenediamines 1 in aqueous sulfuric acid gave the corresponding imidazolines 3. 1,2‐Di‐(4‐pyridyl)ethylenediamine 2 was prepared in 61 % yield by treating N,N'‐di‐t‐ butyl‐oxycarbonyl‐1,2‐di(4‐pyridyl)ethylenediamine 4 with trifluoroacetic acid or in 94% yield by the hydrolysis under basic conditions of N,N' ‐diphthaloylglycyl‐1,2‐di(4‐pyridy)ethylenediamine 13.

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