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Diphenyl cyancarbonimidate and dichlorodiphenoxymethane as synthons for the construction of heterocyclic systems of medicinal interest
Author(s) -
Lee Webb R.,
Eggleston Drake S.,
Labaw Clifford S.,
Lewis Joseph J.,
Wert K.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240153
Subject(s) - chemistry , synthon , yield (engineering) , cimetidine , organic chemistry , combinatorial chemistry , pharmacology , medicine , materials science , metallurgy
Simple high yield methods for the preparation of heterocyclic N ‐cyanoguanidines (including the anti‐ulcer drug cimetidine), substituted triazoles, benzimidazoles and oxadiazoles with anti‐histaminic (H2) activity from the title compounds are described.