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The synthesis of monomethoxynaphtho[1′,2′:4,5]thieno[2,3‐ c ]quinolines
Author(s) -
Pakray Sudabeh,
Castle Raymond N.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240143
Subject(s) - chemistry , thiophene , medicinal chemistry , organic chemistry , combinatorial chemistry , stereochemistry
A series of monomethoxynaphtho[1′,2′:4,5]thieno[2,3‐ c ]quinolines has been prepared by photocyclization of the appropriate N ‐methoxyphenyl‐1‐chloronaphtho[2,1‐ b ]thiophene‐2‐carboxamides. Some of the lactams obtained were converted into the thiolactams and their S ‐methyl derivatives. The lactams were also converted into the corresponding 6‐chloro derivatives. Some of these were catalytically dechlorinated into the monomethoxynaphtho[1′,2′:4,5]thieno[2,3‐ c ]quinolines which were then quaternized into the N ‐methyl quaternary salts.