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Nitration of some 3,5‐disubstituted pyridine N ‐oxides
Author(s) -
Bissell Eugene R.,
Swansiger Rosalind W.
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240113
Subject(s) - chemistry , nitration , pyridine , hydrolysis , pyridine n oxide , oxide , base (topology) , organic chemistry , medicinal chemistry , mathematical analysis , mathematics
The preparation of 3‐chloro‐5‐methoxypyridine N ‐oxide and its nitration are reported. Mononitration yields 5‐chloro‐3‐methoxy‐2‐nitro‐pyridine N ‐oxide while more drastic conditions give 3‐chloro‐5‐methoxy‐2,6‐dinitropyridine. Removal of various substituents by base hydrolysis is also discussed.