Premium
Some chemical transformations of 7a‐cyanohexahydro‐1 H ‐pyrrolizine into 7a‐substituted hexahydro‐1 H ‐pyrrolizines
Author(s) -
Miyano Seiji,
Yamashita Osamu,
Sumoto Kunihiro,
Shima Keiyu,
Hayashimatsu Mariko,
Satoh Fumio
Publication year - 1987
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570240110
Subject(s) - chemistry , aluminum hydride , lithium (medication) , lone pair , nitrogen , medicinal chemistry , hydride , chemical bond , computational chemistry , stereochemistry , organic chemistry , hydrogen , molecule , ion , medicine , endocrinology , methoxide
Chemical transformations of 7a‐cyanohexahydro‐1 H ‐pyrrolizine ( 2 ) into 7a‐substituted hexahydro‐1 H ‐pyrrolizines are described. In the reaction of 2 with lithium aluminum hydride, the orientation of the lone pair of the bridgehead nitrogen against C‐CN bond can be regarded as significant.