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Reaction of pyrazine‐2,3‐dicarbonitrile and 1,3‐dimethyllumazine with alkyl radicals
Author(s) -
Tada Masaru,
Ito Takayori,
Ohshima Kaoru
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230654
Subject(s) - chemistry , pyrazine , radical , alkyl , alkylation , reactivity (psychology) , medicinal chemistry , photochemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology
Pyrazine‐2,3‐dicarbonitrile ( 1 ) reacts with alkyl radicals to give mono‐ 3 and di‐alkylated pyrazine‐2,3‐dicarbonitriles 4 . Similarly 1,3‐dimethyllumazine ( 2 ) reacts with alkyl radicals to give 7‐alkyl‐1,3‐dimethyllumazines 8 as the major product. The reactivity of alkyl radicals decreases in the order tertiary, secondary, and primary, and 1 is more reactive than 2 in those radical substitution reactions.