Reaction of pyrazine‐2,3‐dicarbonitrile and 1,3‐dimethyllumazine with alkyl radicals | Zendy

Tada Masaru | Zendy; Ito Takayori | Zendy; Ohshima Kaoru | Zendy

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Reaction of pyrazine‐2,3‐dicarbonitrile and 1,3‐dimethyllumazine with alkyl radicals

Author(s) -

Tada Masaru,

Ito Takayori,

Ohshima Kaoru

Publication year - 1986

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570230654

Subject(s) - chemistry , pyrazine , radical , alkyl , alkylation , reactivity (psychology) , medicinal chemistry , photochemistry , organic chemistry , catalysis , medicine , alternative medicine , pathology

Pyrazine‐2,3‐dicarbonitrile ( 1 ) reacts with alkyl radicals to give mono‐ 3 and di‐alkylated pyrazine‐2,3‐dicarbonitriles 4 . Similarly 1,3‐dimethyllumazine ( 2 ) reacts with alkyl radicals to give 7‐alkyl‐1,3‐dimethyllumazines 8 as the major product. The reactivity of alkyl radicals decreases in the order tertiary, secondary, and primary, and 1 is more reactive than 2 in those radical substitution reactions.

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