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Transformation of pyrazolo[4,3‐ c ]isothiazoles into 3,4‐disubstituted 1,2‐isothiazoles
Author(s) -
Ueda Taisei,
Shibata Yoshitsugu,
Sakakibara Jinsaku
Publication year - 1986
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570230634
Subject(s) - chemistry , thionyl chloride , ring (chemistry) , transformation (genetics) , medicinal chemistry , pyrazole , chloride , combinatorial chemistry , organic chemistry , biochemistry , gene
Pyrazolo[4,3‐c]isothiazoles 4 and 5 were synthesized by the reaction of 4‐aminoantipyrine 1 with thionyl chloride. Treatment of 4 or 5 with alkylamines underwent pyrazole ring opening to afford 3,4‐disubstituted 1,2‐isothiazoles 8a‐f .