Convenient synthesis of substituted 3‐aminothiophene‐2‐carbonitriles from α‐acetylenic nitriles and their conversion to thieno[3,2‐ d ]pyrimidines | Zendy

Ren WuYun | Zendy; Rao Kambhampati V. B. | Zendy; Klein Robert S. | Zendy

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Convenient synthesis of substituted 3‐aminothiophene‐2‐carbonitriles from α‐acetylenic nitriles and their conversion to thieno[3,2‐ d ]pyrimidines

Author(s) -

Ren WuYun,

Rao Kambhampati V. B.,

Klein Robert S.

Publication year - 1986

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570230631

Subject(s) - chemistry , annulation , conjugate , thiophene , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis , mathematical analysis , mathematics

Several novel 2,4,6‐trisubstituted thieno[3,2‐ d ]pyrimidines were synthesized from the hitherto unknown 3‐amino‐5‐methyl‐(or 5‐phenyl)thiophene‐2‐carbonitriles 7 and 8 . o ‐Aminonitriles 7 and 8 were obtained in a single step by conjugate addition of mercaptoacetonitrile (generated in situ ) to substituted acetylenic nitriles 4 and 5 and annelation of the intermediate vinylic thioethers.

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